Alpha adrenoceptor subtypes responsible for dopamine-induced mesenteric vein contraction.
نویسندگان
چکیده
منابع مشابه
Adrenoceptor study of guinea-pig superior mesenteric--portal vein.
INTRODUCTION Vasoactive agents have been extensively studied in precapillary resistance vessels but little emphasis has been directed to their effect on the venous system even though veins are probably important in governing haemodynamics. Approximately half the blood volume lies within the venous system, therefore a doubling in venous tone could increase the circulating volume by 25% and conve...
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We have investigated the affinity and selectivity of tamsulosin and its metabolites, M1, M2, M3, M4 and AM1, at the tissue and the cloned alpha-1 adrenoceptor subtypes in the radioligand binding and the functional studies. In the radioligand binding studies, the compounds competed for [3H]prazosin binding to the rat liver and kidney alpha-1 adrenoceptors, with the rank order of potency tamsulos...
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OBJECTIVE Crassostrea gigas oyster extract has been reported to have antioxidant, antihypertensive and lipid-lowering properties that may be useful for treating cardiovascular diseases. This study aimed to evaluate the effect of C. gigas oyster extract on cardiovascular function in tissues from healthy rats. METHODS Single-cell microelectrode and isolated thoracic aortic organ bath studies we...
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The effect of specific alpha[ or alpha2 adrenoceptor agents on the response of rat superior mesenteric-portal vein to field stimulation was investigated. In. a dose related manner, phenylephrine (alpha[ agonist) and yohimbine (alpha2 antagonists) increased while prazosin (alpha[ antagonist) and clonidine (alpha2 agonist) decreased the response of the vein to field stimulation. These effects are...
متن کاملMechanism of neurally induced monkey mesenteric artery relaxation and contraction.
Physiological importance in vasodilator innervation alleviating noradrenergic neurogenic vasoconstriction has not been clarified. Isolated monkey mesenteric artery strips denuded of the endothelium responded to nerve stimulation by electrical pulses or nicotine with a contraction, which was potentiated by Ng-nitro-L-arginine, a nitric oxide synthesis inhibitor, but not by the D-enantiomer. The ...
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ژورنال
عنوان ژورنال: The Japanese Journal of Pharmacology
سال: 1984
ISSN: 0021-5198,1347-3506
DOI: 10.1254/jjp.36.253